Epigenetic Modifications of Histone Proteins and Their Role in Transcriptional Dysregulation in Autoimmune Disorders
Keywords:
Epigenetics, Histone Modification, Autoimmune Disorders, Transcriptional Regulation, Chromatin Remodeling, SLE, RA, MSAbstract
Histone modifications, a key epigenetic mechanism, regulate gene expression by altering chromatin structure and accessibility. Aberrations in histone methylation, acetylation, phosphorylation, and ubiquitination contribute significantly to immune dysregulation and the pathogenesis of autoimmune disorders. This short paper explores how histone modifications influence transcriptional control in autoimmune diseases, drawing on findings published prior to 2023. By examining molecular mechanisms and disease-specific histone patterns, we emphasize the therapeutic potential of epigenetic targets in treating conditions such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS).
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Copyright (c) -1 Rachel O’Sullivan (Author)
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