Structural and Functional Brain Connectivity Changes in Early-Stage Alzheimer’s Disease and Their Association with Amyloid Plaque Deposition and Tau Pathology
Keywords:
Alzheimer’s disease, early-stage AD, brain connectivity, amyloid plaques, tau pathology, MRI, PET, neurodegenerationAbstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Early-stage AD is marked by structural and functional alterations in brain connectivity, which are closely associated with the accumulation of amyloid plaques and tau pathology. This research paper examines the changes in brain connectivity in individuals with early-stage AD and explores their correlation with amyloid and tau deposition. Through imaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigate the structural and functional disconnections in various brain networks. The results show that amyloid plaque accumulation and tau pathology significantly contribute to altered brain connectivity, providing potential biomarkers for early diagnosis and progression monitoring of AD.
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Copyright (c) -1 Edoardo Piciocchi (Author)
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