Comprehensive Evaluation of Epigenetic Modifications Induced by Chronic Exposure to Endocrine Disrupting Chemicals and Their Transgenerational Effects
Keywords:
Endocrine-disrupting chemicals, epigenetic modifications, transgenerational effects, DNA methylation, histone modifications, non-coding RNAsAbstract
Endocrine-disrupting chemicals (EDCs) are pervasive environmental pollutants that interfere with hormonal signaling and have been implicated in inducing epigenetic modifications. Chronic exposure to EDCs, such as bisphenol A (BPA), phthalates, and polychlorinated biphenyls (PCBs), has been shown to alter DNA methylation, histone modifications, and non-coding RNA expression, leading to adverse health outcomes. These epigenetic changes can persist across generations, resulting in transgenerational effects that impact disease susceptibility and developmental abnormalities. This paper provides a comprehensive evaluation of the epigenetic mechanisms influenced by EDCs, their role in disease etiology, and the evidence supporting their transgenerational inheritance. By synthesizing findings from recent studies, this review highlights the need for further research to elucidate the long-term consequences of EDC exposure and to inform public health policies aimed at reducing their impact.
References
[1] Kundakovic, Marija, et al. "Sex-Specific Epigenetic Disruption and Behavioral Changes Following Low-Dose in Utero Bisphenol A Exposure." Proceedings of the National Academy of Sciences, vol. 112, no. 22, 2015, pp. 6807–6813.
[2] Walker, Deena M., et al. "PCB-153 Exposure Alters Histone Acetylation and Gene Expression in the Rat Prefrontal Cortex." Toxicological Sciences, vol. 175, no. 1, 2020, pp. 123–134.
[3] Guerrero-Bosagna, Carlos, et al. "Epigenetic Transgenerational Inheritance of Vinclozolin Induced Mouse Adult-Onset Disease and Associated Sperm Epigenome Biomarkers." Reproductive Toxicology, vol. 78, 2018, pp. 130–141.
[4] Zhang, Yan, et al. "Bisphenol A Exposure Alters MicroRNA Expression Profiles in Human Adipose Tissue." Environmental Health Perspectives, vol. 129, no. 4, 2021, p. 047001.
[5] Manikkam, Mohan, et al. "Plastics Derived Endocrine Disruptors (BPA, DEHP, and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease, and Sperm Epimutations." PLoS ONE, vol. 8, no. 1, 2013, p. e55387.
[6] Skinner, Michael K., et al. "Environmentally Induced Epigenetic Transgenerational Inheritance of Sperm Epimutations Promote Genetic Mutations." Epigenetics, vol. 10, no. 8, 2015, pp. 762–771.
[7] Zama, Aparna M., and Mehmet Uzumcu. "Epigenetic Effects of Endocrine-Disrupting Chemicals on Female Reproduction: An Ovarian Perspective." Frontiers in Neuroendocrinology, vol. 31, no. 4, 2010, pp. 420–439.
[8] Casati, Lavinia, et al. "Polychlorinated Biphenyls (PCBs) Alter DNA Methylation and Genomic Integrity in Human Peripheral Blood Mononuclear Cells." Toxicology in Vitro, vol. 29, no. 7, 2015, pp. 1684–1692.
[9] Dolinoy, Dana C., et al. "Maternal Nutrient Supplementation Counteracts Bisphenol A-Induced DNA Hypomethylation in Early Development." Proceedings of the National Academy of Sciences, vol. 104, no. 32, 2007, pp. 13056–13061.
[10] Bruner-Tran, Kaylon L., and Kevin G. Osteen. "Developmental Exposure to TCDD Reduces Fertility and Negatively Affects Pregnancy Outcomes Across Multiple Generations." Reproductive Toxicology, vol. 31, no. 3, 2011, pp. 344–350.
