Severe DRESS Syndrome Induced by Lamotrigine: A Case Report and Review of Diagnostic Challenges
Keywords:
DRESS syndrome, Lamotrigine, Severe cutaneous adverse reaction, Hypersensitivity, Case report, Diagnostic criteriaAbstract
The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a potentially life-threatening severe adverse drug reaction characterized by cutaneous eruptions, hematologic abnormalities, and visceral organ involvement. Lamotrigine, a widely prescribed antiepileptic and mood stabilizer, has increasingly been implicated in DRESS cases. This paper presents a case report of severe lamotrigine-induced DRESS syndrome and examines diagnostic complexities in modern clinical practice. Emphasis is placed on developments in consensus criteria and diagnostic workflows, underscoring the need for early recognition and effective management.
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