Development and Application of Microbiome-Based Diagnostics and Therapeutic Strategies for Managing Inflammatory Bowel Diseases
Keywords:
Microbiome, Inflammatory Bowel Diseases, Diagnostics, Therapeutic Strategies, Fecal Microbiota Transplantation, Probiotics, Gut Microbiota, Chronic InflammationAbstract
The human microbiome plays a crucial role in maintaining health and influencing disease progression. Inflammatory Bowel Diseases (IBD), including Crohn’s Disease (CD) and Ulcerative Colitis (UC), are characterized by chronic inflammation of the gastrointestinal tract, where the gut microbiome is significantly altered. This paper explores the development and application of microbiome-based diagnostics and therapeutic strategies for managing IBD. The integration of microbiome profiling techniques, such as metagenomics and 16S rRNA sequencing, has revolutionized the understanding of IBD pathophysiology. Furthermore, therapeutic interventions, including fecal microbiota transplantation (FMT) and probiotic supplementation, are discussed. The paper outlines significant advancements in microbiome research, including pre-2019 literature, and evaluates their potential in clinical settings.
References
[1] Manichanh, C., et al. "The Role of Microbiota in IBD Pathogenesis." Current Opinion in Gastroenterology, vol. 32, no. 3, 2016, pp. 155–162.
[2] Lozupone, C. A., et al. "Diversity, Stability, and Resilience of the Human Gut Microbiota." Nature, vol. 489, 2016, pp. 220-230.
[3] Mukherjee, R., et al. "Fecal Microbiota Transplantation in IBD: A Systematic Review." Gut, vol. 65, no. 6, 2016, pp. 1104-1115.
[4] Gevers, D., et al. "The Treatment-Resistant Microbiome in Inflammatory Bowel Disease." Journal of Experimental Medicine, vol. 213, 2016, pp. 581–598.
[5] Galipeau, H. J., et al. "Therapeutic Potential of Fecal Microbiota Transplantation for Inflammatory Bowel Disease." Frontiers in Medicine, vol. 5, 2018, pp. 255.
[6] Sokol, H., et al. "Probiotics and Prebiotics in IBD: Therapeutic Potential and Challenges." American Journal of Gastroenterology, vol. 113, 2018, pp. 21-28.
[7] Kump, P. K., et al. "Microbiome in Inflammatory Bowel Diseases: From Pathogenesis to Therapy." World Journal of Gastroenterology, vol. 24, 2018, pp. 2489-2496.
[8] Rausch, P., et al. "Fecal Microbiota Transplantation: A New Frontier in Inflammatory Bowel Disease Therapy." Therapeutic Advances in Gastroenterology, vol. 11, 2018, pp. 39-46.
[9] Frank, D. N., et al. "The Human Microbiome and Inflammatory Bowel Disease." Current Opinion in Gastroenterology, vol. 27, 2017, pp. 1-7.
[10] Sha, S., et al. "Microbiome and Its Role in the Pathogenesis of Inflammatory Bowel Disease." Microorganisms, vol. 7, no. 12, 2019.
[11] Khor, B., et al. "Genetics and Pathogenesis of Inflammatory Bowel Disease." Nature Reviews Gastroenterology & Hepatology, vol. 11, no. 3, 2014, pp. 179-190.
[12] Schirmer, M., et al. "Linking the Human Microbiome to Inflammatory Bowel Disease." Nature, vol. 531, no. 7594, 2016, pp. 10–19.
[13] Ghosh, S., et al. "Biomarkers in IBD: The Next Frontier." World Journal of Gastroenterology, vol. 22, no. 9, 2016, pp. 2518-2528.
[14] Libioulle, C., et al. "The Role of the Microbiome in Inflammatory Bowel Disease." Journal of Gastroenterology, vol. 53, 2018, pp. 137-145.
[15] Tian, L., et al. "Restoring Gut Microbiota in Inflammatory Bowel Disease: An Overview of Therapeutic Options." Biological Therapy, vol. 33, 2017, pp. 1-8.
